| NCT | Title | Condition | Status | Contact |
| NCT03787589 | Exercise in Patients With End Stage Kidney Disease (NCT03787589) | Renal Failure | RECRUITING | |
| NCT06462170 | Pancreatic Insulin Production Capacity (PIPC) - a Feasibility Study (NCT06462170) | Type 2 Diabetes | RECRUITING | |
| NCT06067789 | The ALOFT Pilot Trial (NCT06067789) | Vascular Diseases, Peripheral Artery Disease, Surgery | RECRUITING | emhladkowicz@toh.ca |
| NCT05993013 | Improving Strength and Balance Through Exercise With LudoFit (NCT05993013) | Accidental Falls | RECRUITING | shhuang@toh.ca; tmackenzie@toh.ca |
| NCT05762601 | Cellular precOnditioning for Post-Surgical Myocardial Ischemic Complications - Observational Study (NCT05762601) | Cardiac Complication, Myocardial Infarction, Myocardial Ischemia, Myocardial Injury | RECRUITING | |
| NCT05733416 | Intensive Cancer Screening After Cryptogenic Stroke (NCT05733416) | Occult Cancer | RECRUITING | mdemetrof@ohri.ca |
| NCT05601427 | Intra-Operative Adductor Canal Blocks (NCT05601427) | Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Anesthesia | RECRUITING | shenke@ohri.ca |
| NCT05264285 | Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients (NCT05264285) | Acute Kidney Injury (AKI) | RECRUITING | iwatpool@toh.ca |
| NCT04754061 | PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL) (NCT04754061) | Depression, Anxiety, Distress, Emotional | RECRUITING | jdownar@toh.ca |
| NCT04744675 | Peripheral Nerve Injections for CRPS (NCT04744675) | Complex Regional Pain Syndromes | RECRUITING | |
| NCT05173155 | Comparison of Direct Anterior Approach vs. Lateral Hemiarthroplasty for Femoral Neck Fracture Repair (NCT05173155) | Hip Fractures | RECRUITING | ihorton@ohri.ca |
| NCT05169112 | Impact of Hormonal Therapy on Prostate Cancer Recurrence After Radical Prostatectomy (NCT05169112) | Prostate Cancer | RECRUITING | pjuneau@ohri.ca |
| NCT05149911 | Effect of a Life Coaching Intervention on the Well-being and Distress of Physicians (NCT05149911) | Distress, Emotional, Burnout | RECRUITING | sboet@toh.on.ca |
| NCT04871412 | The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage II (NCT04871412) | Lung Cancer, Gastric Cancer, Esophageal Cancer | RECRUITING | afazekas@toh.ca |
| NCT04671862 | Photobiomodulation for the Prevention of Radiation Induced Oral Mucositis (NCT04671862) | Mucositis Oral, Head and Neck Cancer, Radiation Dermatitis | RECRUITING | mgaudet@toh.ca; krdennis@toh.ca |
| NCT04661787 | Donation Advisor Clinical Decision Support Tool Study (NCT04661787) | Organ Donation | RECRUITING | aseely@ohri.ca |
| NCT04392921 | Prophylaxis for Patients at Risk to Eliminate Post-operative Atrial Fibrillation (NCT04392921) | Atrial Fibrillation | RECRUITING | aseely@ohri.ca |
| NCT04705896 | Albumin To Enhance Recovery After Acute Kidney Injury (NCT04705896) | Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness | RECRUITING | iwatpool@ohri.ca; hlanglois@ohri.ca |
| NCT04080466 | Cam Type FAI is a Cause of Hip Pain in the Young Adult and a Precursor to OA (NCT04080466) | Hip Dysplasia, Femoroacetabular Impingement, Osteoarthritis | RECRUITING | ckreviazuk@ohri.ca |
| NCT03936127 | Comparison of a Novel Transperineal Targeted Fusion Biopsy System to Conventional Transrectal Targeted Fusion Biopsy (NCT03936127) | Prostate Cancer | RECRUITING | nschieda@toh.ca; baschwarz@toh.ca |
| NCT03677713 | Nasal Packing Following Endoscopic Endonasal Pituitary Resection (NCT03677713) | Pituitary Tumor | RECRUITING | alasso@toh.ca |
| NCT04824144 | Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care (NCT04824144) | Hyperactive Delirium, Delirium of Mixed Origin | RECRUITING | |
| NCT02966886 | TSA Techniques in Glenohumeral OA (NCT02966886) | Osteoarthritis, Shoulder | RECRUITING | plapner@toh.on.ca |
| NCT04574960 | Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL) (NCT04574960) | Bladder Cancer, Bladder Urothelial Carcinoma | RECRUITING | pjuneau@ohri.ca |
| NCT05955924 | Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial (NCT05955924) | Non-melanoma Skin Cancer, Carcinoma, Squamous Cell, Carcinoma, Basal Cell, Keratinocyte Carcinoma | RECRUITING | |
| NCT05029063 | Primary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters (NCT05029063) | Venous Thromboembolism, Cancer | RECRUITING | apecarskie@ohri.ca; madhill@ohri.ca |
| NCT00800059 | Total Marrow Irradiation & Autologous Stem Cell Transplantation for Relapsed or Refractory Myeloma (NCT00800059) | Multiple Myeloma | RECRUITING | hatkins@ohri.ca |
| NCT05206747 | Ottawa Sunglasses at Night for Mania Study (NCT05206747) | Mania, Sleep, Bipolar Disorder | RECRUITING | jfiedorowicz@toh.ca |
| NCT06392776 | Early Diagnosis and Treatment of Undiagnosed Asthma or COPD: THE UCAP 2 TRIAL (NCT06392776) | COPD, Asthma | RECRUITING | kvandemheen@toh.ca |
| NCT05255003 | STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis (NCT05255003) | Cancer-associated Thrombosis, Thrombocytopenia | RECRUITING | jbrinkhurst@ohri.ca |
| NCT05969275 | Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock (NCT05969275) | Septic Shock, Sepsis, Pathologic Processes, Shock, Systemic Inflammatory Response Syndrome, Inflammation, Infections | RECRUITING | UCCISS@ohri.ca |
| NCT03175718 | INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients (NCT03175718) | Soft-tissue Sarcoma, Wound Complication | RECRUITING | yalmosuli@ohri.ca |
| NCT05496309 | Causes and Mechanisms of Space Hemolysis at High Altitudes (NCT05496309) | Anemia, Weightlessness | RECRUITING | gtrudel@toh.ca |
| NCT05487274 | TSA v RSA in Osteoarthritic Shoulders With Greater Than 15 Degrees of Retroversion (NCT05487274) | Osteoarthritis Shoulder | RECRUITING | kmcilquham@ohri.ca |
| NCT05325177 | PDA Treatment With Ibuprofen and Changes in Tissue Oxygenation. (NCT05325177) | Patent Ductus Arteriosus After Premature Birth | RECRUITING | |
| NCT05306327 | Neurologic Physiology After Removal of Therapy (NeuPaRT) (NCT05306327) | Determination of Death | RECRUITING | |
| NCT05781113 | A Novel Wearable Digital Biomarker for Detecting Changes in Multiple Sclerosis (MS) Condition (NCT05781113) | Multiple Sclerosis | RECRUITING | gabose@toh.ca |
| NCT05513560 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (NCT05513560) | Long COVID, Post COVID Condition, Post Acute Sequelae of COVID-19 | RECRUITING | |
| NCT04163081 | The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments (NCT04163081) | Nicotine Dependence, Cigarettes, Nicotine Withdrawal | RECRUITING | akapur@ohri.ca |
| NCT03809884 | Dietary Counseling or Potassium Supplement to Increase Potassium Intake in Patients With High Blood Pressure (NCT03809884) | Hypertension | RECRUITING | jbiggs@ohri.ca |
| NCT04935866 | Optimal Brain Oxygenation in Neurologic Intensive Care Unit : The NeurO2 Study (NCT04935866) | Traumatic Brain Injury, Subarachnoid Hemorrhage, Brain Injuries, Near-Infrared Spectroscopy, Intensive Care Neurological Disorder, Anemia | RECRUITING | |
| NCT05506904 | Liberation From Mechanical Ventilation Using Extubation Advisor Decision Support (NCT05506904) | Airway Extubation | RECRUITING | aseely@toh.ca |
| NCT05309226 | Cannabis Use in Pregnancy and Downstream Effects on Maternal and Infant Health (NCT05309226) | Cannabis Use, Marijuana Use | RECRUITING | sramlawi@ohri.ca; alyharvey@ohri.ca |
| NCT05677113 | A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver (NCT05677113) | Colorectal Cancer, Liver Metastases | RECRUITING | roleclerc@ohri.ca |
| NCT05892666 | The Right Care, for the Right Patient, at the Right Time, by the Right Provider: A Value-based Comparison of the Management of Ambulatory Patients With Acute Health Concerns in walk-in Clinics, Primary Care Physician Practices and Emergency Departments (NCT05892666) | Ambulatory Care, Emergency Services, Hospital, Quality of Care, Costs | RECRUITING | jperry@ohri.ca |
| NCT01799967 | Minimally Invasive Surgery of the Gastro-esophageal Junction (NCT01799967) | Achalasia, Paraesophageal Hernia, GERD, Epiphrenic Diverticula, Zenker's Diverticulum | RECRUITING | |
| NCT05899101 | The Impact of Opioid and Cannabis Exposure on Fetal Growth (NCT05899101) | Pregnancy Related, Substance Use, Fetal Growth Retardation, Placenta Diseases | RECRUITING | |
| NCT04180722 | Transition to LIVE (Long-term In Home Ventilation Engagement) Study (NCT04180722) | Long-term Ventilation at Home | RECRUITING | dmckim@toh.on.ca |
| NCT02869802 | Prospectively Defining Metastatic Pancreatic Ductal Adenocarcinoma Subtypes by Comprehensive Genomic Analysis (NCT02869802) | Cancer, Pancreatic Cancer | RECRUITING | |
| NCT05851547 | Dose Escalation For INtraprostatic LEsions (NCT05851547) | Prostatic Neoplasms | RECRUITING | sgrimes@ohri.ca |
| NCT05753618 | Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel Chemotherapy (NCT05753618) | Early-stage Breast Cancer | RECRUITING | lvandermeer@ohri.ca |
| NCT04228419 | TSA vs RSA in Glenohumeral Osteoarthritis (NCT04228419) | Osteoarthritis of the Shoulder | RECRUITING | |
| NCT05326334 | THERApeutic Outcomes Related to Gut microBIOME in Glioblastoma (GBM) Patients Receiving Chemo-radiation (THERABIOME-GBM) (NCT05326334) | Glioblastoma, IDH-wildtype | RECRUITING | |
| NCT04928261 | Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy (NCT04928261) | Breast Cancer | RECRUITING | lvandermeer@ohri.ca |
| NCT02281838 | The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II (NCT02281838) | Intracerebral Hemorrhage | RECRUITING | ddowlat@toh.on.ca |
| NCT05290857 | Anticoagulation After GI Bleeding Pilot Study and Registry (NCT05290857) | GastroIntestinal Bleeding, Anticoagulant-induced Bleeding | RECRUITING | dsiegal@toh.ca |
| NCT05115617 | Pregnant and Lactating Individuals & Newborns COVID-19 Vaccination Prospective Cohort Study (NCT05115617) | SARS-CoV2 Infection, Covid19, Vaccine Reaction, Pregnancy Related, Immunogenicity | RECRUITING | sboyd@ohri.ca; alyharvey@ohri.ca |
| NCT04258475 | The Influence of Concurrent Oral Calcium Carbonate Supplementation on Steady State Pharmacokinetics of Oral Raltegravir. (NCT04258475) | Calcium Supplementation in HIV Patients Using Raltegravir | RECRUITING | nantremblay@toh.ca |
| NCT05466838 | PERT to Improve Quality of Life in Patients Undergoing Pancreaticoduodenectomy: A Pilot Randomized Controlled Trial (NCT05466838) | Pancreatic Insufficiency | RECRUITING | |
| NCT03147859 | Vedolizumab Treatment in Antiretroviral Drug Treated Chronic HIV Infection (NCT03147859) | HIV-infection/AIDS | RECRUITING | bcameron@ohri.ca |
| NCT05078034 | HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT (NCT05078034) | Acute Hypoxemic Respiratory Failure | RECRUITING | aseely@toh.ca |
| NCT04762134 | Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO) (NCT04762134) | Bacterial Sexually Transmitted Diseases | RECRUITING | |
| NCT06168474 | Evaluating Simplified Layered Consent for Clinical Trials (NCT06168474) | Staphylococcus Aureus Bacteremia | RECRUITING | |
| NCT05096195 | PRevEnting FracturEs in REnal Disease 1 (NCT05096195) | Kidney Diseases, Dialysis; Complications, Fragility Fracture, Chronic Kidney Disease-Mineral and Bone Disorder | RECRUITING | judavis@toh.ca |
| NCT02236689 | Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement (NCT02236689) | Tennis Elbow | RECRUITING | |
| NCT05998642 | Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma (NCT05998642) | Non-hodgkin Lymphoma | RECRUITING | |
| NCT06537609 | A Platform Trial for Gram Negative Bloodstream Infections (NCT06537609) | Gram-negative Bacteremia | RECRUITING | |
| NCT04564079 | An Observational Study to Evaluate the Clinical Utility of the Oncomine Precision Assay Within the Exactis Network (NCT04564079) | NSCLC | RECRUITING | natremblay@ohri.ca |
| NCT03663504 | Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery (NCT03663504) | Elective Colon Surgery | RECRUITING | |
| NCT04642430 | COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation (NCT04642430) | Atrial Fibrillation | RECRUITING | lcastellucci@toh.ca; erithomas@toh.ca |
| NCT05804578 | Using a Blood Test to Monitor Metastatic Breast Cancer Treatment (NCT05804578) | Metastatic Breast Cancer | RECRUITING | aawan@ohri.ca |
| NCT02975310 | In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps (NCT02975310) | Sinusitis, Nasal Polyps | RECRUITING | alasso@toh.ca |
| NCT05543941 | Evaluating XPERIENCEâ„¢ Advanced Surgical Irrigation (NCT05543941) | Hip Osteoarthritis, Hip Arthritis, Knee Osteoarthritis, Knee Arthritis | RECRUITING | shenke@ohri.ca |
| NCT03765177 | CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies (NCT03765177) | Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia | RECRUITING | nkekre@toh.on.ca; vlopez@ohri.ca |
| NCT05893147 | BALANCE+ Vanguard Phase (NCT05893147) | Gram-negative Bacteremia | RECRUITING | |
| NCT04624477 | Active Surveillance and Surgery Outcomes in Low Risk Papillary Thyroid Cancer (NCT04624477) | Papillary Thyroid Cancer, Papillary Thyroid Carcinoma, Papillary Microcarcinoma of the Thyroid | RECRUITING | |
| NCT03481010 | Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology (NCT03481010) | Hip Dysplasia | RECRUITING | |
| NCT06131840 | A Study of PF-08046050 (SGN-CEACAM5C) in Adults With Advanced Solid Tumors (NCT06131840) | Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Stomach Neoplasms, Pancreatic Ductal Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Small Cell Lung Carcinoma | RECRUITING | |
| NCT04485195 | RAFF4 Trial: Vernakalant vs. Procainamide for Acute Atrial Fibrillation in the Emergency Department (NCT04485195) | Atrial Fibrillation | RECRUITING | istiell@ohri.ca; ericbrown@ohri.ca |
| NCT04224974 | Emotion and Symptom-Focused Engagement Trial for Individuals With Acute Leukemia (NCT04224974) | Acute Leukemia | RECRUITING | |
| NCT05194072 | A Study of SGN-B7H4V in Advanced Solid Tumors (NCT05194072) | Ovarian Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms, Triple Negative Breast Neoplasms, HER2 Negative Breast Neoplasms, Hormone Receptor Positive Breast Neoplasms, Endometrial Neoplasms, Carcinoma, Non-Small-Cell Lung, Cholangiocarcinoma, Gallbladder Carcinoma, Adenoid Cystic Carcinoma | RECRUITING | |
| NCT05395819 | Clinical Evaluation of Reverse Versus Anatomic Shoulder Arthroplasty Techniques in the Treatment of Osteoarthritis (NCT05395819) | Shoulder Osteoarthritis | RECRUITING | |
| NCT04543110 | Radiation and Durvalumab Immunotherapy As Neoadjuvant Treatment for MIBC (NCT04543110) | Bladder Cancer | RECRUITING | caproulx@ohri.ca |
| NCT05101928 | Ozurdex Monotherapy Trial (NCT05101928) | Uveitis, Posterior, Uveitis, Intermediate, Panuveitis | RECRUITING | mmuir@ohri.ca |
| NCT05605509 | RP-6306 in Patients With Advanced Cancer (NCT05605509) | Advanced Cancer | RECRUITING | |
| NCT06129084 | A Study to Compare the Results of FGFR Testing by Either ctDNA Blood Testing or Standard Tumor Tissue Testing (NCT06129084) | Metastatic Bladder Cancer, Metastatic Urothelial Carcinoma | RECRUITING | sgrimes@toh.ca |
| NCT05066347 | REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCT (NCT05066347) | Syncope | RECRUITING | pnguyen@ohri.ca |
| NCT05258578 | Tele-BARICARE to Manage COVID-19-Related Distress (NCT05258578) | Obesity, Bariatric Surgery Candidate, Mental Health Disorder, Eating Disorders | RECRUITING | dasandre@toh.ca |
| NCT04319627 | Statins for Venous Event Reduction in Patients With Venous Thromboembolism (NCT04319627) | Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome | RECRUITING | jbrinkhurst@ohri.ca |
| NCT05371808 | Economic Analysis of Early vs Delayed Therapy in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: (NCT05371808) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | RECRUITING | |
| NCT04448184 | Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial) (NCT04448184) | Hematologic Neoplasms | RECRUITING | atinmouth@ohri.ca |
| NCT04521413 | Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies (NCT04521413) | Advanced Solid Malignancies | RECRUITING | |
| NCT05364749 | Selective CT for Anticoagulated Head Injured Patients (NCT05364749) | Head Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Traumatic, Blunt Head Injury | RECRUITING | |
| NCT04335292 | Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer With Osimertinib Third-line Rechallenge (NCT04335292) | Non-Small Cell Lung Cancer | RECRUITING | |
| NCT04093167 | Study of CTDNA Response Adaptive Immuno-Chemotherapy in NSCLC (NCT04093167) | Non-Small Cell Lung Cancer | RECRUITING | |
| NCT04874038 | Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) (NCT04874038) | Post-mastectomy Pain Syndrome, Breast Cancer, Pain, Postoperative, Pain, Chronic | RECRUITING | |
| NCT03559114 | PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST) (NCT03559114) | Traumatic Brain Injury | RECRUITING | rporteous@ohri.ca; smiezitis@ohri.ca |
| NCT05246098 | REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI (NCT05246098) | Respiratory Disease, COVID-19, Viral Infection | RECRUITING | aseely@toh.ca |
| NCT05601440 | Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer (NCT05601440) | Breast Cancer | RECRUITING | |
| NCT06410976 | Prospective Clinical Assessment Study in Children With Hypochondroplasia (NCT06410976) | Hypochondroplasia | RECRUITING | |
| NCT04548661 | Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation (NCT04548661) | Surgical Site Infection | RECRUITING | jaboukhalil@toh.ca |
| NCT04274530 | Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial (NCT04274530) | Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed, Fractures, Open | RECRUITING | |
| NCT04415060 | SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival (NCT04415060) | Covid19, Hypoxic Respiratory Failure | RECRUITING | jhaines@toh.ca; iwatpool@toh.ca |
| NCT02960087 | Phase II High Dose Brachytherapy and Low Dose Rate Brachytherapy as Monotherapy in Localized Prostate Cancer (NCT02960087) | Prostate Carcinoma | RECRUITING | |
| NCT03948074 | Cannabis For Cancer-Related Symptoms (NCT03948074) | Pain, Nausea, Anxiety, Sleep Disturbance | RECRUITING | sdownar@ohri.ca |
| NCT04260802 | A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers (NCT04260802) | Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer, Gastric Cancer, Cervical Cancer, Ovarian Cancer, Hepatocellular Carcinoma, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma, Urothelial Neoplasm, Non Small Cell Lung Cancer, Renal Cell Carcinoma, Locally Advanced Solid Tumor, Locally Advanced Malignant Neoplasm, Squamous Cell Carcinoma, Sarcoma, Merkel Cell Carcinoma, Bladder Cancer | RECRUITING | djonker@toh.ca |
| NCT06043427 | Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma (NCT06043427) | Gastroesophageal Adenocarcinoma | RECRUITING | |
| NCT02675569 | ACCESS HD: Comparing Catheters to Fistulas in Elderly Patients Starting Hemodialysis (NCT02675569) | End-stage Kidney Failure | RECRUITING | shiremath@toh.on.ca; jbiggs@ohri.ca |
| NCT02999022 | Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT) (NCT02999022) | Fractures | RECRUITING | spapp@toh.ca; medodd@ohri.ca |
| NCT03297606 | Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (NCT03297606) | Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors | RECRUITING | |
| NCT05714891 | Neoadjuvant Platform Trial in Non-Small Cell Lung Cancer (NCT05714891) | NSCLC | RECRUITING | |
| NCT04580225 | Randomized Comparison of PARtial Wrist Fusion With or Without Triquetral Excision (PARTE) (NCT04580225) | Wrist Arthritis, Wrist Arthropathy, Scapholunate Advanced Collapse, Scaphoid Nonunion, Post-traumatic; Arthrosis, Arthritis, Musculoskeletal Diseases, Joint Diseases | RECRUITING | nagrawal@ohri.ca |
| NCT05428735 | The DRAGON 2 Trial (NCT05428735) | Colorectal Cancer Liver Metastases (CRLM), Small Future Liver Remnant (FLR) | RECRUITING | |
| NCT05795699 | A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD) (NCT05795699) | Fuchs Endothelial Corneal Dystrophy | RECRUITING | |
| NCT05840224 | Study of GS-4528 in Adults With Solid Tumors (NCT05840224) | Solid Tumor | RECRUITING | |
| NCT02906943 | Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943) | Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma, Gynecological Cancer, Genitourinary Cancer, Pancreatobiliary Cancer, Gastrointestinal Cancer, Head and Neck Cancer, Rare Cancer, Unknown Primary Cancer | RECRUITING | hanzhang@ohri.ca; kchristink@toh.ca |
| NCT06182774 | Fixed Duration vs Continuous Daratumumab in Transplant Ineligible Older Adults With Newly Diagnosed Multiple Myeloma (NCT06182774) | Multiple Myeloma | RECRUITING | |
| NCT03569826 | Canadian Network for Autoimmune Liver Disease (NCT03569826) | Primary Bilary Cirrhosis (PBC), Autoimmune Hepatitis, Overlap Syndrome | RECRUITING | angcheung@toh.ca; mmuir@toh.ca |
| NCT04304651 | Screening for Occult Malignancy in Patients With Unprovoked Venous Thromboembolism (NCT04304651) | Embolism and Thrombosis | RECRUITING | adelluc@toh.ca; mcarrier@toh.ca |
| NCT05809999 | IBD Neoplasia Surveillance RCT (NCT05809999) | Colonic Neoplasms, Inflammatory Bowel Diseases, Dysplasia | RECRUITING | |
| NCT04558593 | Surveillance of Complex Renal Cysts - The SOCRATIC Study (NCT04558593) | Complex Renal Cyst | RECRUITING | |
| NCT03419689 | Study Looking at Biomarkers in Ovarian Cancer (NCT03419689) | Gynecologic Cancer | RECRUITING | jweberpals@toh.ca |
| NCT03718260 | PSMA-PET Registry for Recurrent Prostate Cancer (NCT03718260) | Recurrent Prostate Cancer | RECRUITING | dyachnin@ohri.ca |
| NCT04609566 | Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors (NCT04609566) | Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck | RECRUITING | |
| NCT02355171 | Personalize My Treatment (PMT) Registry (NCT02355171) | Cancer | RECRUITING | natremblay@ohri.ca |
| NCT04812366 | Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer (NCT04812366) | Prostate Cancer | RECRUITING | pjuneau@ohri.ca |
| NCT04680442 | Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction (NCT04680442) | Breast Cancer, Heart Failure | RECRUITING | kelross@ohri.ca |
| NCT04065269 | ATr Inhibitor in Combination With Olaparib/Durvalumab (MEDI4736) in Gynaecological Cancers With ARId1A Loss or no Loss (NCT04065269) | Gynaecological Cancers | RECRUITING | |
| NCT06204809 | Safety, Tolerability, PK, and PD Study of PGN-EDODM1 in Participants With Myotonic Dystrophy Type 1 (NCT06204809) | Myotonic Dystrophy 1 | RECRUITING | |
| NCT05180097 | Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma (NCT05180097) | Hodgkin Lymphoma | RECRUITING | |
| NCT03847649 | A Phase II Study of Durvalumab Treatment - Substudy A: In Patients Who Discontinued Prior Checkpoint Therapy Due to Immune Related Toxicity - Substudy B: For Continued Treatment (+/- Tremelimumab) of Patients Previously Enrolled to Completed CCTG Studies (NCT03847649) | Cancer | RECRUITING | |
| NCT06078553 | A Natural History Study in Participants With DOK7 Congenital Myasthenic Syndromes (CMS) (NCT06078553) | Congenital Myasthenic Syndrome | RECRUITING | |
| NCT05481151 | A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV (NCT05481151) | Polycythemia Vera | RECRUITING | dmaassen@ohri.ca |
| NCT04182776 | Fragility Fractures of the Pelvis (FFP) (NCT04182776) | Pelvic Fracture | RECRUITING | |
| NCT03838718 | REtroperitoneal SArcoma Registry: an International Prospective Initiative (NCT03838718) | Retroperitoneal Sarcoma | RECRUITING | cnessim@toh.ca |
| NCT05114096 | Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) (NCT05114096) | Preterm Birth, Premature Birth, Complication of Prematurity, Obstetric Labor, Premature, Pregnancy Complications | RECRUITING | |
| NCT03944798 | Surveillance AFter Extremity Tumor surgerY (NCT03944798) | Soft Tissue Sarcoma, Lung Metastases | RECRUITING | |
| NCT06143046 | A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus in Pregnant Women and in Infants Born to Vaccinated Mothers (NCT06143046) | Respiratory Syncytial Virus | RECRUITING | |
| NCT05913687 | Automated Imaging Differentiation of Parkinsonism (NCT05913687) | Parkinson Disease, Multiple System Atrophy, Parkinson Variant, Progressive Supranuclear Palsy | RECRUITING | tanthompson@ohri.ca |
| NCT05907304 | A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations (NCT05907304) | Advanced or Metastatic Solid Tumors | RECRUITING | |
| NCT02436707 | Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma (NCT02436707) | Lymphoma | RECRUITING | |
| NCT04421820 | BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours (NCT04421820) | Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma | RECRUITING | saali@ohri.ca; roleclerc@ohri.ca |
| NCT03449381 | This Study Aims to Find the Best Dose of BI 907828 (Brigimadlin) in Patients With Different Types of Advanced Cancer (Solid Tumors) (NCT03449381) | Neoplasms | RECRUITING | |
| NCT04401475 | A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC vs. Placebo + SOC in Adult Hospitalized Patients With COVID-19 (NCT04401475) | COVID-19, ARDS | RECRUITING | |
| NCT03636295 | Low INR to Minimize Bleeding With Mechanical Valves Trial (NCT03636295) | Bleeding Post-mechanical Valve Replacement, Thromboembolism Post-mechanical Valve Replacement | RECRUITING | |
| NCT02632448 | A Study of LY2880070 in Participants With Advanced or Metastatic Cancer (NCT02632448) | Solid Tumors, Colorectal Cancer, Breast Cancer, Ovarian Cancer, Colon Cancer, Rectal Cancer, Neoplasms, Endometrial Cancer, Soft Tissue Sarcoma, Triple Negative Breast Cancer, Pancreas Cancer, Pancreatic Cancer | RECRUITING | |
| NCT03261102 | TDM Guided Early Optimization of ADAL in Crohn's Disease (NCT03261102) | Crohn Disease, Drug Monitoring, Inflammatory Bowel Diseases | RECRUITING | metessier@ohri.ca |
| NCT04633655 | International CIPN Assessment and Validation Study (NCT04633655) | Chemotherapy-induced Peripheral Neuropathy, Quality of Life | RECRUITING | krdennis@toh.ca |
| NCT03784755 | Local Ablative Therapy For Hormone Sensitive Oligometastatic Prostate Cancer (NCT03784755) | Prostate Cancer Metastatic | RECRUITING | |
| NCT04635891 | Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD) (NCT04635891) | FSHD | RECRUITING | jemacgregor@ohri.ca; szakutney@ohri.ca |
| NCT05848713 | AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia (NCT05848713) | Community-acquired Pneumonia | RECRUITING | |
| NCT04449874 | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (NCT04449874) | Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors | RECRUITING | |
| NCT04263038 | Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism (NCT04263038) | Pulmonary Embolism, Embolism, Embolism and Thrombosis, Lung Diseases, Cardiovascular Diseases, Respiratory Tract Diseases, Venous Thromboembolism, Anticoagulant-induced Bleeding, Bleeding | RECRUITING | |
| NCT05571839 | A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors (NCT05571839) | Cutaneous Melanoma, Non-small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Neoplasms, Mesothelioma | RECRUITING | |
| NCT06157892 | A Study of Disitamab Vedotin Alone or With Other Anticancer Drugs in Solid Tumors (NCT06157892) | Breast Neoplasms, Gastroesophageal Junction Adenocarcinoma, HER2 Low Breast Neoplasms, HER2 Positive Breast Neoplasms, Stomach Neoplasms, Triple Negative Breast Neoplasms, Metastatic Breast Cancer, Metastatic Gastric Cancer, Advanced Breast Cancer, Advanced Gastric Cancer | RECRUITING | |
| NCT03778502 | DOAC in Unusual Site Venous Thrombosis (NCT03778502) | Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis, Ovarian Vein Thrombosis, Renal Vein Thrombosis, Retinal Vein Thrombosis | RECRUITING | |
| NCT02855476 | HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease (NCT02855476) | Huntington's Disease | RECRUITING | jading@toh.ca |
| NCT04743765 | HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial (NCT04743765) | Hip Fractures, Myocardial Injury | RECRUITING | |
| NCT05171049 | A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE (NCT05171049) | Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism | RECRUITING | |
| NCT04853576 | A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY) (NCT04853576) | Sickle Cell Disease, Hemoglobinopathies | RECRUITING | |
| NCT04035005 | A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (NCT04035005) | Multiple Sclerosis, Primary Progressive | RECRUITING | |
| NCT06179160 | A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation (NCT06179160) | Solid Tumors | RECRUITING | |
| NCT04151342 | CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS) (NCT04151342) | Cancer, Malignancies Multiple, Malignant Solid Tumor, Cancer, Therapy-Related, Molecular Sequence Variation, Genetic Alteration, Gene Fusion, Receptor Tyrosine Kinase Gene Mutation, RTK Family Gene Mutation, Ras (Kras or Nras) Gene Mutation | RECRUITING | |
| NCT03266783 | Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism (NCT03266783) | Venous Thromboembolism | RECRUITING | lcastellucci@toh.ca; erithomas@toh.ca |
| NCT02821013 | Duration of Anti-PD-1 Therapy in Metastatic Melanoma (NCT02821013) | Unresectable/Metastatic Melanoma | RECRUITING | |
| NCT03674307 | Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates (NCT03674307) | Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication | RECRUITING | erithomas@toh.ca; miricci@ohri.ca |
| NCT05253651 | A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer (NCT05253651) | Colorectal Neoplasms | RECRUITING | |
| NCT03573089 | Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE) (NCT03573089) | Kidney Failure, Chronic, Hyperphosphatemia | RECRUITING | shiremath@toh.ca |
| NCT05730036 | A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma (NCT05730036) | Relapsed Refractory Multiple Myeloma (RRMM) | RECRUITING | |
| NCT04530123 | Dose-Ranging Study of the Efficacy and Safety of TAK-101 for Prevention of Gluten-Specific T Cell Activation in Participants With Celiac Disease on a Gluten-Free Diet (NCT04530123) | Celiac Disease | RECRUITING | rsy@toh.on.ca |
| NCT05538130 | A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (NCT05538130) | Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer | RECRUITING | |
| NCT04228991 | Hypofractionated LocoRegional Radiotherapy in Breast Cancer (NCT04228991) | Breast Neoplasms, Radiotherapy, Lymphedema | RECRUITING | |
| NCT02468024 | JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer (NCT02468024) | Non-Small Cell Lung Cancer | RECRUITING | sgilbert@toh.ca; afazekas@toh.ca |
| NCT06206837 | A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer. (NCT06206837) | Breast Cancer | RECRUITING | |
| NCT05625412 | A Study of BMS-986360/CC-90001 Alone and in Combination With Chemotherapy or Nivolumab in Advanced Solid Tumors (NCT05625412) | Advanced Solid Tumors | RECRUITING | |
| NCT05581004 | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05581004) | Locally Advanced or Metastatic Solid Tumors, NSCLC, HNSCC, Melanoma, TNBC, Esophageal Cancer, Gastric Cancer, Cervical Cancer, Urothelial Carcinoma, Clear Cell RCC, HCC | RECRUITING | |
| NCT05376891 | Met Non Small Cell Cancer Registry (MOMENT) (NCT05376891) | Cancer | RECRUITING | pwheatleyprice@toh.ca |
| NCT05773274 | Comparing Retreatment of 177Lu-DOTATATE PRRT Versus Everolimus in Patients With Metastatic Unresectable Midgut Neuroendocrine Tumors, NET RETREAT Trial (NCT05773274) | Metastatic Midgut Neuroendocrine Tumor, Metastatic Midgut Neuroendocrine Tumor G1, Metastatic Midgut Neuroendocrine Tumor G2, Unresectable Midgut Neuroendocrine Tumor | RECRUITING | |
| NCT03127631 | A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (NCT03127631) | Prostate Cancer, Cardiovascular Disease | RECRUITING | dyachnin@toh.ca |
| NCT05686070 | A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke (NCT05686070) | Prevention of Ischemic Stroke, Acute Non-cardioembolic Ischemic Stroke, High-risk Transient Ischemic Attack | RECRUITING | |
| NCT01574053 | Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort (NCT01574053) | Huntington's Disease | RECRUITING | jading@toh.ca |
| NCT02735707 | Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (NCT02735707) | Community-acquired Pneumonia, Influenza, COVID-19 | RECRUITING | |
| NCT05171075 | A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE (NCT05171075) | Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism | RECRUITING | |
| NCT05548127 | TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A) (NCT05548127) | Breast Cancer | RECRUITING | |
| NCT03969953 | Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease (NCT03969953) | Chronic Kidney Diseases, Dialysis-dependent Kidney Failure, Cardiovascular Disease | RECRUITING | |
| NCT05909904 | Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma (NCT05909904) | Head and Neck Squamous Cell Carcinoma, Head and Neck Cancer | RECRUITING | |
| NCT03496883 | Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial (NCT03496883) | Intracerebral Hemorrhage | RECRUITING | ddowlat@toh.ca |
| NCT05355701 | A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. (NCT05355701) | Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma | RECRUITING | |
| NCT04895709 | A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors (NCT04895709) | Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Urothelial Carcinoma, Pancreatic Adenocarcinoma, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms | RECRUITING | |
| NCT05573555 | TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B) (NCT05573555) | Breast Cancer | RECRUITING | |
| NCT05257083 | A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma (NCT05257083) | Multiple Myeloma | RECRUITING | |
| NCT05696626 | Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation (NCT05696626) | Metastatic Breast Cancer | RECRUITING | |
| NCT04477785 | PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort (NCT04477785) | Parkinson Disease | RECRUITING | |
| NCT05090566 | MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma (NCT05090566) | Multiple Myeloma | RECRUITING | |
| NCT05650632 | A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma (NCT05650632) | Multiple Myeloma | RECRUITING | |
| NCT03020303 | Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease (NCT03020303) | Endstage Renal Disease | RECRUITING | dzimmerman@toh.on.ca |
| NCT04167527 | Endovascular Therapy for Low NIHSS Ischemic Strokes (NCT04167527) | Cerebral Ischemia | RECRUITING | |
| NCT05379595 | A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer (NCT05379595) | Advanced or Metastatic Colorectal Cancer | RECRUITING | |
| NCT05625399 | A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma (NCT05625399) | Melanoma | RECRUITING | |
| NCT04894591 | To Assess the Effectiveness and Safety of Zepzelca in Adult Patients With Extensive Stage Small Cell Lung Cancer (SCLC) (NCT04894591) | Extensive-stage Small-cell Lung Cancer | RECRUITING | |
| NCT03151629 | International Registry for Men With Advanced Prostate Cancer (IRONMAN) (NCT03151629) | Prostate Cancer | RECRUITING | |
| NCT05430971 | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry (NCT05430971) | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) | RECRUITING | |
| NCT05933057 | Efficacy, Safety and Tolerability of Givinostat in Non-ambulant Patients With Duchenne Muscular Dystrophy (NCT05933057) | Duchenne Muscular Dystrophy | RECRUITING | |
| NCT06084936 | A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma (NCT06084936) | Lymphoma | RECRUITING | |
| NCT05137119 | Staphylococcus Aureus Network Adaptive Platform Trial (NCT05137119) | Staphylococcus Aureus Bacteremia | RECRUITING | |
| NCT05811351 | A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD) (NCT05811351) | Geographic Atrophy | RECRUITING | |
| NCT03860883 | Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (NCT03860883) | Cutaneous Melanoma, Stage II | RECRUITING | cnessim@toh.ca |
| NCT04663308 | A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC) (NCT04663308) | Primary Sclerosing Cholangitis | RECRUITING | |
| NCT05382299 | Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382299) | Triple Negative Breast Cancer, PD-L1 Negative | RECRUITING | |
| NCT04613596 | Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7 (NCT04613596) | Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer | RECRUITING | |
| NCT05382286 | Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382286) | Triple Negative Breast Cancer, PD-L1 Positive | RECRUITING | |
| NCT03968393 | Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery (NCT03968393) | Stroke, Atrial Fibrillation | RECRUITING | |
| NCT05502341 | Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen (NCT05502341) | HIV-1-infection | RECRUITING | |
| NCT04951622 | A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis (NCT04951622) | Myasthenia Gravis | RECRUITING | |
| NCT05217446 | A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer (NCT05217446) | Metastatic Colorectal Cancer | RECRUITING | |
| NCT05325866 | A Study Evaluating Bemarituzumab in Solid Tumors With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression (NCT05325866) | Solid Tumors | RECRUITING | |
| NCT04728893 | Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) (NCT04728893) | Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia | RECRUITING | |
| NCT06047080 | An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma (NCT06047080) | Large B-Cell Lymphoma | RECRUITING | |
| NCT04529122 | A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test (NCT04529122) | Solid Tumours | RECRUITING | |
| NCT06136624 | Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003) (NCT06136624) | Prostate Cancer Metastatic | RECRUITING | |
| NCT04961567 | A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus (NCT04961567) | Lupus Erythematosus, Systemic | RECRUITING | |
| NCT05646862 | A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy (NCT05646862) | Breast Cancer | RECRUITING | |
| NCT04031677 | Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (NCT04031677) | Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma | RECRUITING | |
| NCT03950076 | EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF) (NCT03950076) | Intracranial Hemorrhages, Atrial Fibrillation | RECRUITING | |
| NCT04589845 | Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study (NCT04589845) | Solid Tumors | RECRUITING | |
| NCT06032546 | A Study to Assess Change in Disease Activity, Adverse Events, and How the Drug Moves Through the Body in Adult Participants Living With Human Immunodeficiency Virus (HIV) Receiving Intravenous (IV) Infusion of Budigalimab and/or ABBV-382 (NCT06032546) | Human Immuno-deficiency Virus (HIV) Disease | RECRUITING | |
| NCT05445778 | Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer (GLORIOSA) (NCT05445778) | Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer | RECRUITING | jweberpals@toh.ca |
| NCT05358717 | A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) (NCT05358717) | Huntington Disease | RECRUITING | |
| NCT06136559 | A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011) (NCT06136559) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | RECRUITING | |
| NCT05111574 | Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery (NCT05111574) | Anal Melanoma, Bladder Melanoma, Cervical Melanoma, Esophageal Melanoma, Gallbladder Melanoma, Mucosal Melanoma, Mucosal Melanoma of the Head and Neck, Mucosal Melanoma of the Urinary System, Nasopharyngeal Melanoma, Oral Cavity Mucosal Melanoma, Penile Mucosal Melanoma, Rectal Melanoma, Recurrent Mucosal Melanoma, Sinonasal Mucosal Melanoma, Stage II Vulvar Cancer AJCC v8, Stage III Vulvar Cancer AJCC v8, Stage IV Vulvar Cancer AJCC v8, Urethral Melanoma, Vaginal Melanoma, Vulvar Melanoma | RECRUITING | |
| NCT03233191 | Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer (NCT03233191) | Breast Screening | RECRUITING | |
| NCT04340141 | Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer (NCT04340141) | Pancreatic Adenosquamous Carcinoma, Resectable Pancreatic Adenocarcinoma, Pancreatic Cancer | RECRUITING | |
| NCT04513717 | Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial (NCT04513717) | Metastatic Malignant Neoplasm in the Bone, Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8, Stage IIIB Prostate Cancer AJCC v8, Stage IIIC Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8 | RECRUITING | |
| NCT05174169 | Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (NCT05174169) | Stage III Colon Cancer | RECRUITING | |
| NCT04269902 | Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study (NCT04269902) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | RECRUITING | |
| NCT03488693 | Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (NCT03488693) | Breast Cancer | RECRUITING | |
| NCT03486873 | Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587) (NCT03486873) | Solid Tumors, Hematologic Malignancies | RECRUITING | |
