| NCT | Title | Condition | Status | Contact |
| NCT03787589 | Exercise in Patients With End Stage Kidney Disease (NCT03787589) | Renal Failure | RECRUITING | |
| NCT06067789 | The ALOFT Pilot Trial (NCT06067789) | Vascular Diseases, Peripheral Artery Disease, Surgery | RECRUITING | emhladkowicz@toh.ca |
| NCT06042491 | The STRIVE Before Surgery Pilot Trial (NCT06042491) | Surgery-Complications, Disability Physical | RECRUITING | kbranje@ohri.ca |
| NCT05993013 | Improving Strength and Balance Through Exercise With LudoFit (NCT05993013) | Accidental Falls | RECRUITING | shhuang@toh.ca; tmackenzie@toh.ca |
| NCT05762601 | Cellular precOnditioning for Post-Surgical Myocardial Ischemic Complications - Observational Study (NCT05762601) | Cardiac Complication, Myocardial Infarction, Myocardial Ischemia, Myocardial Injury | RECRUITING | |
| NCT05733416 | Intensive Cancer Screening After Cryptogenic Stroke (NCT05733416) | Occult Cancer | RECRUITING | mdemetrof@ohri.ca |
| NCT05601427 | Intra-Operative Adductor Canal Blocks (NCT05601427) | Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Anesthesia | RECRUITING | shenke@ohri.ca |
| NCT05264285 | Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients (NCT05264285) | Acute Kidney Injury (AKI) | RECRUITING | iwatpool@toh.ca |
| NCT04754061 | PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL) (NCT04754061) | Depression, Anxiety, Distress, Emotional | RECRUITING | jdownar@toh.ca |
| NCT05173155 | Comparison of Direct Anterior Approach vs. Lateral Hemiarthroplasty for Femoral Neck Fracture Repair (NCT05173155) | Hip Fractures | RECRUITING | ihorton@ohri.ca |
| NCT05169112 | Impact of Hormonal Therapy on Prostate Cancer Recurrence After Radical Prostatectomy (NCT05169112) | Prostate Cancer | RECRUITING | pjuneau@ohri.ca |
| NCT05149911 | Effect of a Life Coaching Intervention on the Well-being and Distress of Physicians (NCT05149911) | Distress, Emotional, Burnout | RECRUITING | sboet@toh.on.ca |
| NCT04921137 | Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With Lower Risk Breast Cancer (NCT04921137) | Breast Cancer | RECRUITING | msavard@toh.ca |
| NCT04871412 | The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage II (NCT04871412) | Lung Cancer, Gastric Cancer, Esophageal Cancer | RECRUITING | afazekas@toh.ca |
| NCT04671862 | Photobiomodulation for the Prevention of Radiation Induced Oral Mucositis (NCT04671862) | Mucositis Oral, Head and Neck Cancer, Radiation Dermatitis | RECRUITING | mgaudet@toh.ca; krdennis@toh.ca |
| NCT04661787 | Donation Advisor Clinical Decision Support Tool Study (NCT04661787) | Organ Donation | RECRUITING | aseely@ohri.ca |
| NCT04392921 | Prophylaxis for Patients at Risk to Eliminate Post-operative Atrial Fibrillation (NCT04392921) | Atrial Fibrillation | RECRUITING | aseely@ohri.ca |
| NCT04705896 | Albumin To Enhance Recovery After Acute Kidney Injury (NCT04705896) | Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness | RECRUITING | iwatpool@ohri.ca; hlanglois@ohri.ca |
| NCT04105179 | How TKA Implants Affect Muscle Quality and Activity During Daily Living and Immunological Response (NCT04105179) | Osteoarthritis, Knee, Inflammation Knees | RECRUITING | |
| NCT04080466 | Cam Type FAI is a Cause of Hip Pain in the Young Adult and a Precursor to OA (NCT04080466) | Hip Dysplasia, Femoroacetabular Impingement, Osteoarthritis | RECRUITING | ckreviazuk@ohri.ca |
| NCT03936127 | Comparison of a Novel Transperineal Targeted Fusion Biopsy System to Conventional Transrectal Targeted Fusion Biopsy (NCT03936127) | Prostate Cancer | RECRUITING | nschieda@toh.ca; baschwarz@toh.ca |
| NCT03806114 | Dislocation Precautions (NCT03806114) | Arthroplasty, Hip Replacement, Arthroplasties, Hip Replacement, Health-Related Quality Of Life | RECRUITING | jdobransky@ohri.ca |
| NCT03746925 | Comparing Short-term Outcomes After Direct Anterior and SuperPATH Hip Arthroplasty Approaches (NCT03746925) | Arthroplasty, Replacement, Hip | RECRUITING | jdobransky@ohri.ca |
| NCT03713255 | Mid-point Transverse Process to Pleura Block for Breast Cancer Surgery: A Randomized Controlled Trial (NCT03713255) | Breast Cancer, Acute Pain, Anesthesia | RECRUITING | |
| NCT03677713 | Nasal Packing Following Endoscopic Endonasal Pituitary Resection (NCT03677713) | Pituitary Tumor | RECRUITING | alasso@toh.ca |
| NCT04824144 | Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care (NCT04824144) | Hyperactive Delirium, Delirium of Mixed Origin | RECRUITING | |
| NCT03100110 | NeuroCognitive Communicator: Safety Study (NCT03100110) | Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Tetraplegia | RECRUITING | rdoole@ohri.ca |
| NCT03031873 | Evaluation of Susceptibility-weighted Magnetic Resonance Imaging and 4d-time-resolved Magnetic Resonance Angiography in Brain Arteriovenous Malformations (NCT03031873) | Arteriovenous Malformations | RECRUITING | baschwarz@toh.ca |
| NCT02966886 | TSA Techniques in Glenohumeral OA (NCT02966886) | Osteoarthritis, Shoulder | RECRUITING | plapner@toh.on.ca |
| NCT04574960 | Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL) (NCT04574960) | Bladder Cancer, Bladder Urothelial Carcinoma | RECRUITING | pjuneau@ohri.ca |
| NCT05955924 | Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial (NCT05955924) | Non-melanoma Skin Cancer, Carcinoma, Squamous Cell, Carcinoma, Basal Cell, Keratinocyte Carcinoma | RECRUITING | |
| NCT05029063 | Primary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters (NCT05029063) | Venous Thromboembolism, Cancer | RECRUITING | apecarskie@ohri.ca; madhill@ohri.ca |
| NCT05206747 | Ottawa Sunglasses at Night for Mania Study (NCT05206747) | Mania, Sleep, Bipolar Disorder | RECRUITING | jfiedorowicz@toh.ca |
| NCT00800059 | Total Marrow Irradiation & Autologous Stem Cell Transplantation for Relapsed or Refractory Myeloma (NCT00800059) | Multiple Myeloma | RECRUITING | hatkins@ohri.ca |
| NCT05255003 | STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis (NCT05255003) | Cancer-associated Thrombosis, Thrombocytopenia | RECRUITING | jbrinkhurst@ohri.ca |
| NCT05969275 | Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock (NCT05969275) | Septic Shock, Sepsis, Pathologic Processes, Shock, Systemic Inflammatory Response Syndrome, Inflammation, Infections | RECRUITING | UCCISS@ohri.ca |
| NCT03175718 | INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients (NCT03175718) | Soft-tissue Sarcoma, Wound Complication | RECRUITING | yalmosuli@ohri.ca |
| NCT05496309 | Causes and Mechanisms of Space Hemolysis at High Altitudes (NCT05496309) | Anemia, Weightlessness | RECRUITING | gtrudel@toh.ca |
| NCT05487274 | TSA v RSA in Osteoarthritic Shoulders With Greater Than 15 Degrees of Retroversion (NCT05487274) | Osteoarthritis Shoulder | RECRUITING | kmcilquham@ohri.ca |
| NCT05093075 | Therapeutic Plasma Exchange in Septic Shock: A Pilot Study (NCT05093075) | Septic Shock | RECRUITING | |
| NCT05306327 | Neurologic Physiology After Removal of Therapy (NeuPaRT) (NCT05306327) | Determination of Death | RECRUITING | |
| NCT05781113 | A Novel Wearable Digital Biomarker for Detecting Changes in Multiple Sclerosis (MS) Condition (NCT05781113) | Multiple Sclerosis | RECRUITING | gabose@toh.ca |
| NCT05325177 | PDA Treatment With Ibuprofen and Changes in Tissue Oxygenation. (NCT05325177) | Patent Ductus Arteriosus After Premature Birth | RECRUITING | |
| NCT05513560 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (NCT05513560) | Long COVID, Post COVID Condition, Post Acute Sequelae of COVID-19 | RECRUITING | |
| NCT05019963 | Enhancing COVID Rehabilitation With Technology (NCT05019963) | Covid19 | RECRUITING | kwells@ohri.ca |
| NCT04935866 | Optimal Brain Oxygenation in Neurologic Intensive Care Unit : The NeurO2 Study (NCT04935866) | Traumatic Brain Injury, Subarachnoid Hemorrhage, Brain Injuries, Near-Infrared Spectroscopy, Intensive Care Neurological Disorder, Anemia | RECRUITING | |
| NCT03809884 | Dietary Counseling or Potassium Supplement to Increase Potassium Intake in Patients With High Blood Pressure (NCT03809884) | Hypertension | RECRUITING | jbiggs@ohri.ca |
| NCT05309226 | Cannabis Use in Pregnancy and Downstream Effects on Maternal and Infant Health (NCT05309226) | Cannabis Use, Marijuana Use | RECRUITING | sramlawi@ohri.ca; alyharvey@ohri.ca |
| NCT05677113 | A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver (NCT05677113) | Colorectal Cancer, Liver Metastases | RECRUITING | roleclerc@ohri.ca |
| NCT05096195 | PRevEnting FracturEs in REnal Disease 1 (NCT05096195) | Kidney Diseases, Dialysis; Complications, Fragility Fracture, Chronic Kidney Disease-Mineral and Bone Disorder | RECRUITING | judavis@toh.ca |
| NCT05892666 | The Right Care, for the Right Patient, at the Right Time, by the Right Provider: A Value-based Comparison of the Management of Ambulatory Patients With Acute Health Concerns in walk-in Clinics, Primary Care Physician Practices and Emergency Departments (NCT05892666) | Ambulatory Care, Emergency Services, Hospital, Quality of Care, Costs | RECRUITING | jperry@ohri.ca |
| NCT01799967 | Minimally Invasive Surgery of the Gastro-esophageal Junction (NCT01799967) | Achalasia, Paraesophageal Hernia, GERD, Epiphrenic Diverticula, Zenker's Diverticulum | RECRUITING | |
| NCT05899101 | The Impact of Opioid and Cannabis Exposure on Fetal Growth (NCT05899101) | Pregnancy Related, Substance Use, Fetal Growth Retardation, Placenta Diseases | RECRUITING | |
| NCT04180722 | Transition to LIVE (Long-term In Home Ventilation Engagement) Study (NCT04180722) | Long-term Ventilation at Home | RECRUITING | dmckim@toh.on.ca |
| NCT02869802 | Prospectively Defining Metastatic Pancreatic Ductal Adenocarcinoma Subtypes by Comprehensive Genomic Analysis (NCT02869802) | Cancer, Pancreatic Cancer | RECRUITING | |
| NCT05851547 | Dose Escalation For INtraprostatic LEsions (NCT05851547) | Prostatic Neoplasms | RECRUITING | sgrimes@ohri.ca |
| NCT05754528 | Evaluating an Endocrine Therapy Dose-frequency Escalation Strategy and Its Effects on Tolerability and Compliance (NCT05754528) | Breast Cancer | RECRUITING | lvandermeer@ohri.ca |
| NCT05753618 | Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel Chemotherapy (NCT05753618) | Early-stage Breast Cancer | RECRUITING | lvandermeer@ohri.ca |
| NCT04228419 | TSA vs RSA in Glenohumeral Osteoarthritis (NCT04228419) | Osteoarthritis of the Shoulder | RECRUITING | |
| NCT04642430 | COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation (NCT04642430) | Atrial Fibrillation | RECRUITING | lcastellucci@toh.ca; erithomas@toh.ca |
| NCT05326334 | THERApeutic Outcomes Related to Gut microBIOME in Glioblastoma (GBM) Patients Receiving Chemo-radiation (THERABIOME-GBM) (NCT05326334) | Glioblastoma, IDH-wildtype | RECRUITING | |
| NCT04928261 | Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy (NCT04928261) | Breast Cancer | RECRUITING | lvandermeer@ohri.ca |
| NCT02281838 | The Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial II (NCT02281838) | Intracerebral Hemorrhage | RECRUITING | ddowlat@toh.on.ca |
| NCT04708509 | Extubation Advisor: Initial Implementation and Evaluation of a Novel Extubation Clinical Decision Support Tool (NCT04708509) | Airway Extubation | RECRUITING | |
| NCT04549207 | Comparing Continuation or De-escalation of Bone Modifying Agents (BMA) in Patients Treated for Over 2 Years for Bone Metastases From Either Breast or Castration-resistant Prostate Cancer (NCT04549207) | Breast Cancer, Castration-resistant Prostate Cancer | RECRUITING | |
| NCT05078034 | HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT (NCT05078034) | Acute Hypoxemic Respiratory Failure | RECRUITING | aseely@toh.ca |
| NCT05290857 | Anticoagulation After GI Bleeding Pilot Study and Registry (NCT05290857) | GastroIntestinal Bleeding, Anticoagulant-induced Bleeding | RECRUITING | dsiegal@toh.ca |
| NCT05115617 | Pregnant and Lactating Individuals & Newborns COVID-19 Vaccination Prospective Cohort Study (NCT05115617) | SARS-CoV2 Infection, Covid19, Vaccine Reaction, Pregnancy Related, Immunogenicity | RECRUITING | sboyd@ohri.ca; alyharvey@ohri.ca |
| NCT04258475 | The Influence of Concurrent Oral Calcium Carbonate Supplementation on Steady State Pharmacokinetics of Oral Raltegravir. (NCT04258475) | Calcium Supplementation in HIV Patients Using Raltegravir | RECRUITING | nantremblay@toh.ca |
| NCT05466838 | PERT to Improve Quality of Life in Patients Undergoing Pancreaticoduodenectomy: A Pilot Randomized Controlled Trial (NCT05466838) | Pancreatic Insufficiency | RECRUITING | |
| NCT03147859 | Vedolizumab Treatment in Antiretroviral Drug Treated Chronic HIV Infection (NCT03147859) | HIV-infection/AIDS | RECRUITING | bcameron@ohri.ca |
| NCT06168474 | Evaluating Simplified Layered Consent for Clinical Trials (NCT06168474) | Staphylococcus Aureus Bacteremia | RECRUITING | |
| NCT05893147 | BALANCE+ Vanguard Phase (NCT05893147) | Gram-negative Bacteremia | RECRUITING | |
| NCT02236689 | Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement (NCT02236689) | Tennis Elbow | RECRUITING | |
| NCT04224974 | Emotion and Symptom-Focused Engagement Trial for Individuals With Acute Leukemia (NCT04224974) | Acute Leukemia | RECRUITING | |
| NCT05998642 | Ibrutinib Combination Therapy in Transplant Ineligible Individuals With Newly Diagnosed Primary CNS Lymphoma (NCT05998642) | Non-hodgkin Lymphoma | RECRUITING | |
| NCT04564079 | An Observational Study to Evaluate the Clinical Utility of the Oncomine Precision Assay Within the Exactis Network (NCT04564079) | NSCLC | RECRUITING | natremblay@ohri.ca |
| NCT03663504 | Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery (NCT03663504) | Elective Colon Surgery | RECRUITING | |
| NCT05804578 | Using a Blood Test to Monitor Metastatic Breast Cancer Treatment (NCT05804578) | Metastatic Breast Cancer | RECRUITING | aawan@ohri.ca |
| NCT05852262 | High-dose Cephalexin for Cellulitis (HI-DOCC) (NCT05852262) | Cellulitis | RECRUITING | kyadav@toh.ca; gsandino@ohri.ca |
| NCT05605509 | RP-6306 in Patients With Advanced Cancer (NCT05605509) | Advanced Cancer | RECRUITING | |
| NCT05543941 | Evaluating XPERIENCEâ„¢ Advanced Surgical Irrigation (NCT05543941) | Hip Osteoarthritis, Hip Arthritis, Knee Osteoarthritis, Knee Arthritis | RECRUITING | shenke@ohri.ca |
| NCT02975310 | In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps (NCT02975310) | Sinusitis, Nasal Polyps | RECRUITING | alasso@toh.ca |
| NCT03765177 | CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies (NCT03765177) | Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia | RECRUITING | nkekre@toh.on.ca; vlopez@ohri.ca |
| NCT05371808 | Economic Analysis of Early vs Delayed Therapy in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: (NCT05371808) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | RECRUITING | |
| NCT04624477 | Active Surveillance and Surgery Outcomes in Low Risk Papillary Thyroid Cancer (NCT04624477) | Papillary Thyroid Cancer, Papillary Thyroid Carcinoma, Papillary Microcarcinoma of the Thyroid | RECRUITING | |
| NCT03481010 | Periacetabular Osteotomy With and Without Arthroscopic Management of Central Compartment Pathology (NCT03481010) | Hip Dysplasia | RECRUITING | |
| NCT03715478 | Multi-Center Study of GSK2857916 in Combination With Pomalidomide and Dex (NCT03715478) | Relapsed and/or Refractory Multiple Myeloma | RECRUITING | |
| NCT04045587 | International Severe Asthma Registry: Canadian Cohort (NCT04045587) | Severe Asthma | RECRUITING | kvandemheen@ohri.ca |
| NCT04485195 | RAFF4 Trial: Vernakalant vs. Procainamide for Acute Atrial Fibrillation in the Emergency Department (NCT04485195) | Atrial Fibrillation | RECRUITING | istiell@ohri.ca; ericbrown@ohri.ca |
| NCT06078553 | A Natural History Study in Participants With DOK7 Congenital Myasthenic Syndromes (CMS) (NCT06078553) | Congenital Myasthenic Syndrome | RECRUITING | |
| NCT05194072 | A Study of SGN-B7H4V in Advanced Solid Tumors (NCT05194072) | Ovarian Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms, Triple Negative Breast Neoplasms, HER2 Negative Breast Neoplasms, Hormone Receptor Positive Breast Neoplasms, Endometrial Neoplasms, Carcinoma, Non-Small-Cell Lung, Cholangiocarcinoma, Gallbladder Carcinoma, Adenoid Cystic Carcinoma | RECRUITING | |
| NCT04624906 | Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia (NCT04624906) | Waldenstrom Macroglobulinemia | RECRUITING | |
| NCT05395819 | Clinical Evaluation of Reverse Versus Anatomic Shoulder Arthroplasty Techniques in the Treatment of Osteoarthritis (NCT05395819) | Shoulder Osteoarthritis | RECRUITING | |
| NCT04543110 | Radiation and Durvalumab Immunotherapy As Neoadjuvant Treatment for MIBC (NCT04543110) | Bladder Cancer | RECRUITING | caproulx@ohri.ca |
| NCT05601440 | Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer (NCT05601440) | Breast Cancer | RECRUITING | |
| NCT06129084 | A Study to Compare the Results of FGFR Testing by Either ctDNA Blood Testing or Standard Tumor Tissue Testing (NCT06129084) | Metastatic Bladder Cancer, Metastatic Urothelial Carcinoma | RECRUITING | sgrimes@toh.ca |
| NCT05101928 | Ozurdex Monotherapy Trial (NCT05101928) | Uveitis, Posterior, Uveitis, Intermediate, Panuveitis | RECRUITING | mmuir@ohri.ca |
| NCT05066347 | REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCT (NCT05066347) | Syncope | RECRUITING | pnguyen@ohri.ca |
| NCT05258578 | Tele-BARICARE to Manage COVID-19-Related Distress (NCT05258578) | Obesity, Bariatric Surgery Candidate, Mental Health Disorder, Eating Disorders | RECRUITING | dasandre@toh.ca |
| NCT04319627 | Statins for Venous Event Reduction in Patients With Venous Thromboembolism (NCT04319627) | Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome | RECRUITING | jbrinkhurst@ohri.ca |
| NCT06204809 | Safety, Tolerability, PK, and PD Study of PGN-EDODM1 in Participants With Myotonic Dystrophy Type 1 (NCT06204809) | Myotonic Dystrophy 1 | RECRUITING | |
| NCT04448184 | Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial) (NCT04448184) | Hematologic Neoplasms | RECRUITING | atinmouth@ohri.ca |
| NCT04521413 | Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies (NCT04521413) | Advanced Solid Malignancies | RECRUITING | |
| NCT05364749 | Selective CT for Anticoagulated Head Injured Patients (NCT05364749) | Head Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Traumatic, Blunt Head Injury | RECRUITING | |
| NCT04335292 | Osimertinib Then Chemotherapy in EGFR-mutated Lung Cancer With Osimertinib Third-line Rechallenge (NCT04335292) | Non-Small Cell Lung Cancer | RECRUITING | |
| NCT04093167 | Study of CTDNA Response Adaptive Immuno-Chemotherapy in NSCLC (NCT04093167) | Non-Small Cell Lung Cancer | RECRUITING | |
| NCT04874038 | Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) (NCT04874038) | Post-mastectomy Pain Syndrome, Breast Cancer, Pain, Postoperative, Pain, Chronic | RECRUITING | |
| NCT02960087 | Phase II High Dose Brachytherapy and Low Dose Rate Brachytherapy as Monotherapy in Localized Prostate Cancer (NCT02960087) | Prostate Carcinoma | RECRUITING | |
| NCT04812366 | Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer (NCT04812366) | Prostate Cancer | RECRUITING | pjuneau@ohri.ca |
| NCT03559114 | PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST) (NCT03559114) | Traumatic Brain Injury | RECRUITING | rporteous@ohri.ca; smiezitis@ohri.ca |
| NCT05246098 | REVIVe: Frailty, Rehabilitation, and Outcomes in Critically Ill Adult and Pediatric Survivors of COVID-19 or ARI (NCT05246098) | Respiratory Disease, COVID-19, Viral Infection | RECRUITING | aseely@toh.ca |
| NCT04138706 | Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection (NCT04138706) | Clostridium Difficile Infection | RECRUITING | maidris@ohri.ca |
| NCT04580225 | Randomized Comparison of PARtial Wrist Fusion With or Without Triquetral Excision (PARTE) (NCT04580225) | Wrist Arthritis, Wrist Arthropathy, Scapholunate Advanced Collapse, Scaphoid Nonunion, Post-traumatic; Arthrosis, Arthritis, Musculoskeletal Diseases, Joint Diseases | RECRUITING | nagrawal@ohri.ca |
| NCT04548661 | Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation (NCT04548661) | Surgical Site Infection | RECRUITING | jaboukhalil@toh.ca |
| NCT04274530 | Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial (NCT04274530) | Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed, Fractures, Open | RECRUITING | |
| NCT04415060 | SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival (NCT04415060) | Covid19, Hypoxic Respiratory Failure | RECRUITING | jhaines@toh.ca; iwatpool@toh.ca |
| NCT03948074 | Cannabis For Cancer-Related Symptoms (NCT03948074) | Pain, Nausea, Anxiety, Sleep Disturbance | RECRUITING | sdownar@ohri.ca |
| NCT04260802 | A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers (NCT04260802) | Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer, Gastric Cancer, Cervical Cancer, Ovarian Cancer, Hepatocellular Carcinoma, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma, Urothelial Neoplasm, Non Small Cell Lung Cancer, Renal Cell Carcinoma, Locally Advanced Solid Tumor, Locally Advanced Malignant Neoplasm, Squamous Cell Carcinoma, Sarcoma, Merkel Cell Carcinoma, Bladder Cancer | RECRUITING | djonker@toh.ca |
| NCT05707208 | A Randomized, Controlled Study of Repeat Dose Sustained Release Lidocaine for Treatment of Chronic Scrotal Pain (NCT05707208) | Chronic Pain | RECRUITING | amanross@toh.ca |
| NCT02675569 | ACCESS HD: Comparing Catheters to Fistulas in Elderly Patients Starting Hemodialysis (NCT02675569) | End-stage Kidney Failure | RECRUITING | shiremath@toh.on.ca; jbiggs@ohri.ca |
| NCT02999022 | Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT) (NCT02999022) | Fractures | RECRUITING | spapp@toh.ca; medodd@ohri.ca |
| NCT05714891 | Neoadjuvant Platform Trial in Non-Small Cell Lung Cancer (NCT05714891) | NSCLC | RECRUITING | |
| NCT05428735 | The DRAGON 2 Trial (NCT05428735) | Colorectal Cancer Liver Metastases (CRLM), Small Future Liver Remnant (FLR) | RECRUITING | |
| NCT05795699 | A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD) (NCT05795699) | Fuchs Endothelial Corneal Dystrophy | RECRUITING | |
| NCT05840224 | Study of GS-4528 in Adults With Solid Tumors (NCT05840224) | Solid Tumor | RECRUITING | |
| NCT02906943 | Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943) | Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma, Gynecological Cancer, Genitourinary Cancer, Pancreatobiliary Cancer, Gastrointestinal Cancer, Head and Neck Cancer, Rare Cancer, Unknown Primary Cancer | RECRUITING | hanzhang@ohri.ca; kchristink@toh.ca |
| NCT03569826 | Canadian Network for Autoimmune Liver Disease (NCT03569826) | Primary Bilary Cirrhosis (PBC), Autoimmune Hepatitis, Overlap Syndrome | RECRUITING | angcheung@toh.ca; mmuir@toh.ca |
| NCT04609566 | Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors (NCT04609566) | Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck | RECRUITING | |
| NCT05809999 | IBD Neoplasia Surveillance RCT (NCT05809999) | Colonic Neoplasms, Inflammatory Bowel Diseases, Dysplasia | RECRUITING | |
| NCT04304651 | Screening for Occult Malignancy in Patients With Unprovoked Venous Thromboembolism (NCT04304651) | Embolism and Thrombosis | RECRUITING | adelluc@toh.ca; mcarrier@toh.ca |
| NCT03297606 | Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (NCT03297606) | Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors | RECRUITING | |
| NCT04558593 | Surveillance of Complex Renal Cysts - The SOCRATIC Study (NCT04558593) | Complex Renal Cyst | RECRUITING | |
| NCT03419689 | Study Looking at Biomarkers in Ovarian Cancer (NCT03419689) | Gynecologic Cancer | RECRUITING | jweberpals@toh.ca |
| NCT03718260 | PSMA-PET Registry for Recurrent Prostate Cancer (NCT03718260) | Recurrent Prostate Cancer | RECRUITING | dyachnin@ohri.ca |
| NCT02355171 | Personalize My Treatment (PMT) Registry (NCT02355171) | Cancer | RECRUITING | natremblay@ohri.ca |
| NCT04680442 | Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction (NCT04680442) | Breast Cancer, Heart Failure | RECRUITING | kelross@ohri.ca |
| NCT05180097 | Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma (NCT05180097) | Hodgkin Lymphoma | RECRUITING | |
| NCT05487235 | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-1971 in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05487235) | Advanced Solid Tumors, Metastatic Solid Tumors | RECRUITING | |
| NCT04803747 | A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery (NCT04803747) | Major Non-cardiac Surgeries | RECRUITING | emhladkowicz@toh.ca; nkhalil@ohri.ca |
| NCT05032196 | Study of WVE-003 in Patients With Huntington's Disease (NCT05032196) | Huntington Disease | RECRUITING | tanthompson@ohri.ca |
| NCT05481151 | A Study to Assess Efficacy, Safety, and Tolerability of P1101 in Adult Patients With PV (NCT05481151) | Polycythemia Vera | RECRUITING | dmaassen@ohri.ca |
| NCT04182776 | Fragility Fractures of the Pelvis (FFP) (NCT04182776) | Pelvic Fracture | RECRUITING | |
| NCT03847649 | A Phase II Study of Durvalumab Treatment - Substudy A: In Patients Who Discontinued Prior Checkpoint Therapy Due to Immune Related Toxicity - Substudy B: For Continued Treatment (+/- Tremelimumab) of Patients Previously Enrolled to Completed CCTG Studies (NCT03847649) | Cancer | RECRUITING | |
| NCT03838718 | REtroperitoneal SArcoma Registry: an International Prospective Initiative (NCT03838718) | Retroperitoneal Sarcoma | RECRUITING | cnessim@toh.ca |
| NCT05114096 | Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) (NCT05114096) | Preterm Birth, Premature Birth, Complication of Prematurity, Obstetric Labor, Premature, Pregnancy Complications | RECRUITING | |
| NCT03944798 | Surveillance AFter Extremity Tumor surgerY (NCT03944798) | Soft Tissue Sarcoma, Lung Metastases | RECRUITING | |
| NCT06143046 | A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus in Pregnant Women and in Infants Born to Vaccinated Mothers (NCT06143046) | Respiratory Syncytial Virus | RECRUITING | |
| NCT04263038 | Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism (NCT04263038) | Pulmonary Embolism, Embolism, Embolism and Thrombosis, Lung Diseases, Cardiovascular Diseases, Respiratory Tract Diseases, Venous Thromboembolism, Anticoagulant-induced Bleeding, Bleeding | RECRUITING | |
| NCT05137119 | Staphylococcus Aureus Network Adaptive Platform Trial (NCT05137119) | Staphylococcus Aureus Bacteremia | RECRUITING | |
| NCT05913687 | Automated Imaging Differentiation of Parkinsonism (NCT05913687) | Parkinson Disease, Multiple System Atrophy, Parkinson Variant, Progressive Supranuclear Palsy | RECRUITING | tanthompson@ohri.ca |
| NCT05907304 | A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations (NCT05907304) | Advanced or Metastatic Solid Tumors | RECRUITING | |
| NCT02436707 | Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma (NCT02436707) | Lymphoma | RECRUITING | |
| NCT04401475 | A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC vs. Placebo + SOC in Adult Hospitalized Patients With COVID-19 (NCT04401475) | COVID-19, ARDS | RECRUITING | |
| NCT05848713 | AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia (NCT05848713) | Community-acquired Pneumonia | RECRUITING | |
| NCT03449381 | This Study Aims to Find the Best Dose of BI 907828 (Brigimadlin) in Patients With Different Types of Advanced Cancer (Solid Tumors) (NCT03449381) | Neoplasms | RECRUITING | |
| NCT02632448 | A Study of LY2880070 in Participants With Advanced or Metastatic Cancer (NCT02632448) | Solid Tumors, Colorectal Cancer, Breast Cancer, Ovarian Cancer, Colon Cancer, Rectal Cancer, Neoplasms, Endometrial Cancer, Soft Tissue Sarcoma, Triple Negative Breast Cancer, Pancreas Cancer, Pancreatic Cancer | RECRUITING | |
| NCT04633655 | International CIPN Assessment and Validation Study (NCT04633655) | Chemotherapy-induced Peripheral Neuropathy, Quality of Life | RECRUITING | krdennis@toh.ca |
| NCT03784755 | Local Ablative Therapy For Hormone Sensitive Oligometastatic Prostate Cancer (NCT03784755) | Prostate Cancer Metastatic | RECRUITING | |
| NCT03261102 | TDM Guided Early Optimization of ADAL in Crohn's Disease (NCT03261102) | Crohn Disease, Drug Monitoring, Inflammatory Bowel Diseases | RECRUITING | metessier@ohri.ca |
| NCT04635891 | Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD) (NCT04635891) | FSHD | RECRUITING | jemacgregor@ohri.ca; szakutney@ohri.ca |
| NCT05571839 | A Study of SGN-BB228 in Advanced Melanoma and Other Solid Tumors (NCT05571839) | Cutaneous Melanoma, Non-small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Neoplasms, Mesothelioma | RECRUITING | |
| NCT04449874 | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (NCT04449874) | Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors | RECRUITING | |
| NCT04151342 | CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS) (NCT04151342) | Cancer, Malignancies Multiple, Malignant Solid Tumor, Cancer, Therapy-Related, Molecular Sequence Variation, Genetic Alteration, Gene Fusion, Receptor Tyrosine Kinase Gene Mutation, RTK Family Gene Mutation, Ras (Kras or Nras) Gene Mutation | RECRUITING | |
| NCT02855476 | HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease (NCT02855476) | Huntington's Disease | RECRUITING | jading@toh.ca |
| NCT03778502 | DOAC in Unusual Site Venous Thrombosis (NCT03778502) | Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis, Ovarian Vein Thrombosis, Renal Vein Thrombosis, Retinal Vein Thrombosis | RECRUITING | |
| NCT04743765 | HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial (NCT04743765) | Hip Fractures, Myocardial Injury | RECRUITING | |
| NCT03266783 | Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism (NCT03266783) | Venous Thromboembolism | RECRUITING | lcastellucci@toh.ca; erithomas@toh.ca |
| NCT05171049 | A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE (NCT05171049) | Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism | RECRUITING | |
| NCT04853576 | A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY) (NCT04853576) | Sickle Cell Disease, Hemoglobinopathies | RECRUITING | |
| NCT04035005 | A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (NCT04035005) | Multiple Sclerosis, Primary Progressive | RECRUITING | |
| NCT04683848 | Study to Assess the Efficacy and Safety of MT-3921 in Subjects With Acute Traumatic Cervical Spinal Cord Injury (NCT04683848) | Spinal Cord Injury | RECRUITING | |
| NCT03674307 | Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates (NCT03674307) | Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication | RECRUITING | erithomas@toh.ca; miricci@ohri.ca |
| NCT02821013 | Duration of Anti-PD-1 Therapy in Metastatic Melanoma (NCT02821013) | Unresectable/Metastatic Melanoma | RECRUITING | |
| NCT05253651 | A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer (NCT05253651) | Colorectal Neoplasms | RECRUITING | |
| NCT04650581 | Fulvestrant and Ipatasertib for Advanced HER-2 Negative and Estrogen Receptor Positive (ER+) Breast Cancer Following Progression on First Line CDK 4/6 Inhibitor and Aromatase Inhibitor (NCT04650581) | Breast Cancer | RECRUITING | |
| NCT05151172 | EndovaSCular TreAtment to imProve outcomEs for Medium Vessel Occlusions (ESCAPE-MeVO Trial) (NCT05151172) | Acute Ischemic Stroke | RECRUITING | mdemetrof@ohri.ca |
| NCT03573089 | Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE) (NCT03573089) | Kidney Failure, Chronic, Hyperphosphatemia | RECRUITING | shiremath@toh.ca |
| NCT03975647 | A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer (NCT03975647) | HER2-positive Breast Cancer | RECRUITING | |
| NCT05538130 | A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (NCT05538130) | Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer | RECRUITING | |
| NCT04228991 | Hypofractionated LocoRegional Radiotherapy in Breast Cancer (NCT04228991) | Breast Neoplasms, Radiotherapy, Lymphedema | RECRUITING | |
| NCT04675294 | Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03) (NCT04675294) | Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | RECRUITING | |
| NCT02468024 | JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer (NCT02468024) | Non-Small Cell Lung Cancer | RECRUITING | sgilbert@toh.ca; afazekas@toh.ca |
| NCT05625412 | A Study of BMS-986360/CC-90001 Alone and in Combination With Chemotherapy or Nivolumab in Advanced Solid Tumors (NCT05625412) | Advanced Solid Tumors | RECRUITING | |
| NCT05581004 | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05581004) | Locally Advanced or Metastatic Solid Tumors, NSCLC, HNSCC, Melanoma, TNBC, Esophageal Cancer, Gastric Cancer, Cervical Cancer, Urothelial Carcinoma, Clear Cell RCC, HCC | RECRUITING | |
| NCT05376891 | Met Non Small Cell Cancer Registry (MOMENT) (NCT05376891) | Cancer | RECRUITING | pwheatleyprice@toh.ca |
| NCT05686070 | A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke (NCT05686070) | Prevention of Ischemic Stroke, Acute Non-cardioembolic Ischemic Stroke, High-risk Transient Ischemic Attack | RECRUITING | |
| NCT05171075 | A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE (NCT05171075) | Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism | RECRUITING | |
| NCT02735707 | Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (NCT02735707) | Community-acquired Pneumonia, Influenza, COVID-19 | RECRUITING | |
| NCT03127631 | A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (NCT03127631) | Prostate Cancer, Cardiovascular Disease | RECRUITING | dyachnin@toh.ca |
| NCT01574053 | Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort (NCT01574053) | Huntington's Disease | RECRUITING | jading@toh.ca |
| NCT05355701 | A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. (NCT05355701) | Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma | RECRUITING | |
| NCT05819359 | Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD (NCT05819359) | Parkinson's Disease | RECRUITING | |
| NCT05548127 | TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A) (NCT05548127) | Breast Cancer | RECRUITING | |
| NCT03969953 | Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease (NCT03969953) | Chronic Kidney Diseases, Dialysis-dependent Kidney Failure, Cardiovascular Disease | RECRUITING | |
| NCT05573555 | TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B) (NCT05573555) | Breast Cancer | RECRUITING | |
| NCT06136559 | A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011) (NCT06136559) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | RECRUITING | |
| NCT05257083 | A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma (NCT05257083) | Multiple Myeloma | RECRUITING | |
| NCT03496883 | Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial (NCT03496883) | Intracerebral Hemorrhage | RECRUITING | ddowlat@toh.ca |
| NCT04895709 | A Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors (NCT04895709) | Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Urothelial Carcinoma, Pancreatic Adenocarcinoma, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms | RECRUITING | |
| NCT05696626 | Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation (NCT05696626) | Metastatic Breast Cancer | RECRUITING | |
| NCT04477785 | PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort (NCT04477785) | Parkinson Disease | RECRUITING | |
| NCT05090566 | MagnetisMM-4: Umbrella Study of Elranatamab (PF-06863135) in Combination With Anti-Cancer Treatments in Multiple Myeloma (NCT05090566) | Multiple Myeloma | RECRUITING | |
| NCT05650632 | A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma (NCT05650632) | Multiple Myeloma | RECRUITING | |
| NCT05430971 | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry (NCT05430971) | Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) | RECRUITING | |
| NCT04167527 | Endovascular Therapy for Low NIHSS Ischemic Strokes (NCT04167527) | Cerebral Ischemia | RECRUITING | ddowlat@toh.ca; zdaham@ohri.ca |
| NCT03020303 | Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease (NCT03020303) | Endstage Renal Disease | RECRUITING | dzimmerman@toh.on.ca |
| NCT05379595 | A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer (NCT05379595) | Advanced or Metastatic Colorectal Cancer | RECRUITING | |
| NCT05176639 | A Safety, Tolerability and Efficacy Study of VRDN 001 in Healthy Volunteers and Persons With Thyroid Eye Disease (TED) (NCT05176639) | Thyroid Eye Disease | RECRUITING | |
| NCT05625399 | A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma (NCT05625399) | Melanoma | RECRUITING | |
| NCT04894591 | To Assess the Effectiveness and Safety of Zepzelca in Adult Patients With Extensive Stage Small Cell Lung Cancer (SCLC) (NCT04894591) | Extensive-stage Small-cell Lung Cancer | RECRUITING | |
| NCT05933057 | Efficacy, Safety and Tolerability of Givinostat in Non-ambulant Patients With Duchenne Muscular Dystrophy (NCT05933057) | Duchenne Muscular Dystrophy | RECRUITING | |
| NCT03151629 | International Registry for Men With Advanced Prostate Cancer (IRONMAN) (NCT03151629) | Prostate Cancer | RECRUITING | |
| NCT05568095 | A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body (NCT05568095) | Advanced Upper Gastrointestinal Tract Adenocarcinoma | RECRUITING | |
| NCT05811351 | A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD) (NCT05811351) | Geographic Atrophy | RECRUITING | |
| NCT03860883 | Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma (NCT03860883) | Cutaneous Melanoma, Stage II | RECRUITING | cnessim@toh.ca |
| NCT04663308 | A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC) (NCT04663308) | Primary Sclerosing Cholangitis | RECRUITING | |
| NCT05184712 | Phase 3 Clinical Study of AK112 for NSCLC Patients (NCT05184712) | Non-Squamous Non-small Cell Lung Cancer | RECRUITING | |
| NCT05132582 | A Study of Tucatinib or Placebo With Trastuzumab and Pertuzumab for Metastatic HER2+ Breast Cancer (NCT05132582) | HER2 Positive Breast Cancer | RECRUITING | |
| NCT05382299 | Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician's Choice in Patients With Previously Untreated Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382299) | Triple Negative Breast Cancer, PD-L1 Negative | RECRUITING | |
| NCT05488314 | A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer (NCT05488314) | Carcinoma, Non-Small-Cell Lung | RECRUITING | |
| NCT05382286 | Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer (NCT05382286) | Triple Negative Breast Cancer, PD-L1 Positive | RECRUITING | |
| NCT05502341 | Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen (NCT05502341) | HIV-1-infection | RECRUITING | |
| NCT03968393 | Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery (NCT03968393) | Stroke, Atrial Fibrillation | RECRUITING | |
| NCT06254482 | An Extension Study to Evaluate the Long-Term Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) (NCT06254482) | Huntington Disease | RECRUITING | |
| NCT05217446 | A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer (NCT05217446) | Metastatic Colorectal Cancer | RECRUITING | |
| NCT05327530 | A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley) (NCT05327530) | Locally Advanced or Metastatic Urothelial Carcinoma | RECRUITING | |
| NCT05325866 | A Study Evaluating Bemarituzumab in Solid Tumors With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression (NCT05325866) | Solid Tumors | RECRUITING | |
| NCT04951622 | A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis (NCT04951622) | Myasthenia Gravis | RECRUITING | |
| NCT04728893 | Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) (NCT04728893) | Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia | RECRUITING | |
| NCT05049798 | A Study of Guselkumab and Interleukin-17 (IL-17) Inhibitor Therapies in Participants With Psoriatic Arthritis in Routine Clinical Practice (NCT05049798) | Arthritis, Psoriatic | RECRUITING | |
| NCT05445778 | Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer (GLORIOSA) (NCT05445778) | Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer | RECRUITING | jweberpals@toh.ca |
| NCT05840211 | Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy (NCT05840211) | Locally Advanced or Unresectable Metastatic Breast Cancer, Stage IV Breast Cancer | RECRUITING | |
| NCT05646862 | A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy (NCT05646862) | Breast Cancer | RECRUITING | |
| NCT04529122 | A Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test (NCT04529122) | Solid Tumours | RECRUITING | |
| NCT04961567 | A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Systemic Lupus Erythematosus (NCT04961567) | Lupus Erythematosus, Systemic | RECRUITING | |
| NCT04031677 | Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (NCT04031677) | Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma | RECRUITING | |
| NCT05827016 | A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma (NCT05827016) | Multiple Myeloma | RECRUITING | |
| NCT03950076 | EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF) (NCT03950076) | Intracranial Hemorrhages, Atrial Fibrillation | RECRUITING | |
| NCT05665595 | A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010) (NCT05665595) | Melanoma | RECRUITING | |
| NCT04589845 | Tumor-Agnostic Precision Immuno-Oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study (NCT04589845) | Solid Tumors | RECRUITING | |
| NCT04295538 | Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI) (NCT04295538) | Spinal Cord Injury (SCI) | RECRUITING | |
| NCT05358717 | A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD) (NCT05358717) | Huntington Disease | RECRUITING | |
| NCT05052801 | Bemarituzumab or Placebo Plus Chemotherapy in Gastric Cancers With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression (NCT05052801) | Gastric Cancer, Gastroesophageal Junction Adenocarcinoma | RECRUITING | |
| NCT05523167 | A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy. (NCT05523167) | Active Idiopathic Inflammatory Myopathy, Myositis, Dermatomyositis, Polymyositis, Immune-Mediated Necrotizing Myopathy, Antisynthetase Syndrome | RECRUITING | |
| NCT05768854 | Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfecta (NCT05768854) | Osteogenesis Imperfecta | RECRUITING | |
| NCT04468984 | Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis (NCT04468984) | Myelofibrosis (MF) | RECRUITING | |
| NCT03233191 | Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer (NCT03233191) | Breast Screening | RECRUITING | |
| NCT04340141 | Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer (NCT04340141) | Pancreatic Adenosquamous Carcinoma, Resectable Pancreatic Adenocarcinoma, Pancreatic Cancer | RECRUITING | |
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